Design of Probabilistic Boolean Networks Based on Network Structure and Steady-State Probabilities

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Steady-state probabilities for attractors in probabilistic Boolean networks

Boolean networks form a class of disordered dynamical systems that have been studied in physics owing to their relationships with disordered systems in statistical mechanics and in biology as models of genetic regulatory networks. Recently they have been generalized to probabilistic Boolean networks (PBNs) to facilitate the incorporation of uncertainty in the model and to represent cellular con...

متن کامل

GPU-Accelerated Steady-State Computation of Large Probabilistic Boolean Networks

Computation of steady-state probabilities is an important aspect of analysing biological systems modelled as probabilistic Boolean networks (PBNs). For small PBNs, efficient numerical methods can be successfully applied to perform the computation with the use of Markov chain state transition matrix underlying the studied networks. However, for large PBNs, numerical methods suffer from the state...

متن کامل

State reduction for network intervention in probabilistic Boolean networks

MOTIVATION A key goal of studying biological systems is to design therapeutic intervention strategies. Probabilistic Boolean networks (PBNs) constitute a mathematical model which enables modeling, predicting and intervening in their long-run behavior using Markov chain theory. The long-run dynamics of a PBN, as represented by its steady-state distribution (SSD), can guide the design of effectiv...

متن کامل

Steady-State Analysis of Genetic Regulatory Networks Modelled by Probabilistic Boolean Networks

Probabilistic Boolean networks (PBNs) have recently been introduced as a promising class of models of genetic regulatory networks. The dynamic behaviour of PBNs can be analysed in the context of Markov chains. A key goal is the determination of the steady-state (long-run) behaviour of a PBN by analysing the corresponding Markov chain. This allows one to compute the long-term influence of a gene...

متن کامل

An approximation method for solving the steady-state probability distribution of probabilistic Boolean networks

MOTIVATION Probabilistic Boolean networks (PBNs) have been proposed to model genetic regulatory interactions. The steady-state probability distribution of a PBN gives important information about the captured genetic network. The computation of the steady-state probability distribution usually includes construction of the transition probability matrix and computation of the steady-state probabil...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: IEEE Transactions on Neural Networks and Learning Systems

سال: 2017

ISSN: 2162-237X,2162-2388

DOI: 10.1109/tnnls.2016.2572063